Pull the thread on any gene or variant. See what science actually knows and what it doesn't.
Choose a thread to pull
Each journey walks you through a gene, a variant, or a question, with evidence at every step.
Every thread tells a story when you follow it far enough.
Walk through BRCA1 — from what it does in your cells, to what a variant means, to how interpretations have changed over 20 years.
Certainty shatters. The pieces remain.
What happens when a genetic test returns a VUS? Explore why uncertainty is the most common result, and what it means for you.
Frequencies move with people.
Explore how migration, isolation, and admixture created the genetic variation we see today — and why population matters in clinical interpretation.
Every drawer holds a question someone once thought was answered.
MTHFR variants are common and mostly benign. But the story of how they became a wellness obsession tells us something about genetic literacy.
Time writes itself into everything that lives.
ClinVar tracks how variant interpretations change over time. See real examples of reclassification — and why it's a feature, not a bug.
The evidence is always in the footnotes.
Some variants we carry today were present in populations thousands of years ago. Explore what ancient DNA studies are uncovering about the deep history of human genetic variation.
Every thread tells a story when you follow it far enough.
Enter a gene symbol and we'll compose a narrative thread from live data — ClinVar, gnomAD, ClinGen, and GTEx. Pull the thread on any gene.